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Invitrogen™ RGMA Polyclonal Antibody
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Catalog No. PIPA565378
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100 μL
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Catalog No. Quantity
PIPA565378 100 μL
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Catalog No. PIPA565378 Supplier Invitrogen™ Supplier No. PA565378
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: RYLTFAVRMPE EVVNAVEDWD SQGLYLCLRG CPLNQQIDFQ AFHTNAEGTG ARRLAAASPA PTAPETFPYE TAVAKCKEKL PVE Highest antigen sequence identity to the following orthologs - mouse 87%, rat 87%.

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RGMA
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RGMA
Gene Accession No. Q96B86
Gene Alias BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA
Gene Symbols RGMA
Host Species Rabbit
Immunogen Recombinant Human RGMA. Recombinant protein control fragment (Product #RP-104789).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56963
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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