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Invitrogen™ RGMA Recombinant Rabbit Monoclonal Antibody (2S1B4)
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Catalog No. PIMA542630
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100 μL
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PIMA542630 100 μL
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Catalog No. PIMA542630 Supplier Invitrogen™ Supplier No. MA542630
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Description

Rabbit Recombinant Monoclonal Antibody

Positive test controls include: Mouse heart, Rat skeletal muscle,Rat heart. The target is usually found in the following locations: Cell membrane, GPI-anchor, Lipid-anchor. Immunogen sequence: TAPETFPYET AVAKCKEKLP VEDLYYQACV FDLLTTGDVN FTLAAYYALE DVKMLHSNKD KLHLYERTRD LPGRAAAGLP LAPRPLLGAL VPLLALLPVF C.

Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RGMA
Applications ELISA, Western Blot
Classification Recombinant Monoclonal
Clone 2S1B4
Concentration 0.67 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
Gene RGMA
Gene Accession No. Q6PCX7
Gene Alias BC059072; C230063O06; repulsive guidance molecule; repulsive guidance molecule A; repulsive guidance molecule family member a; RGM; RGM domain family member A; RGM domain family, member A; RGMA
Gene Symbols RGMA
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 350-450 of human RGMA (Q96B86).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 244058, 308739
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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