Invitrogen™ RGR Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596864

Catalog No. PIPA596864

Description

Immunogen sequence: HYDYEPLGTC CTLDYSKGDR NFTSFLFTMS FFNFAMPLFI TITSYSLMEQ KLGKSGHLQV NTTLPARTLL LGWGPYAILY LYAVIADVTS ISPKLQMVPA LIAKMVPTIN AINYALGNEM VCRGIWQCLS PQKREKDRTK; Positive Samples: rat spinal cord; Cellular Location: Membrane, Multi-pass membrane protein.

This gene encodes a putative retinal G-protein coupled receptor. The gene is a member of the opsin subfamily of the 7 transmembrane, G-protein coupled receptor 1 family. Like other opsins which bind retinaldehyde, it contains a conserved lysine residue in the seventh transmembrane domain. The protein acts as a photoisomerase to catalyze the conversion of all-trans-retinal to 11-cis-retinal. The reverse isomerization occurs with rhodopsin in retinal photoreceptor cells. The protein is exclusively expressed in tissue adjacent to retinal photoreceptor cells, the retinal pigment epithelium and Mueller cells. This gene may be associated with autosomal recessive and autosomal dominant retinitis pigmentosa (arRP and adRP, respectively). Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: RGR
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RGR
• Gene Alias: retinal G protein coupled receptor; Rgr; RGR opsin; RGR-opsin; RP44; RPE retinal G-protein coupled receptor; RPE-retinal G protein-coupled receptor
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 306307, 5995
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.84 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P47804
• Gene Symbols: RGR
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 156-295 of human RGR (NP_0029122).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat
• Product Type: Antibody
• Isotype: IgG