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Invitrogen™ RGS14 Polyclonal Antibody
Goat Polyclonal Antibody
Supplier: Invitrogen™ PA518278
Description
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
RGS14 is a member of the regulator of G-protein signaling family which contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. RGS14 attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. The resulting hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of RGS14 have been observed but have not been thoroughly characterized. Further, RGS14 acts as a positive modulator of microtubule polymerisation and spindle organization through a G(i)-alpha-dependent mechanism; plays a role in cell division; is required for the nerve growth factor (NGF)-mediated neurite outgrowth, and is involved in stress resistance. RGS14 protein may also be involved in visual memory processing capacity and hippocampal-based learning and memory.
Specifications
RGS14 | |
Polyclonal | |
Unconjugated | |
Rgs14 | |
rap1/rap2 interacting protein; RAP1/RAP2-interacting protein; Regulator of G-protein signaling 14; regulator of G-protein signalling 14; RGS14; RGSE; RPIP1 | |
Goat | |
Ammonium sulfate precipitation | |
RUO | |
10636 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot | |
0.5 mg/mL | |
TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3 | |
O43566 | |
Rgs14 | |
Synthetic peptide sequence (IGGSLNSTTDSAL) corresponding to the C-terminus amino acids of RGS14 (aa 554-566). | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG |
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