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Invitrogen™ RGS21 Polyclonal Antibody
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Catalog No. PIPA5104094
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100 μL
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PIPA5104094 100 μL
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Catalog No. PIPA5104094 Supplier Invitrogen™ Supplier No. PA5104094
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total RGS21.

Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS21 is a recently identified member of this family that has been reported to be selectively expressed in subpopulations of taste bud cells and co-expressed with bitter and sweet transduction components such as alpha-gusticin, phospholipase Cbeta2, T1R2/T1R3 sweet taste receptors and T2R bitter taste receptors. Other reports indicate that RGS21 is more widely expressed. Binding assays demonstrate that RGS21 binds alpha-gusticin in a conformation-dependent manner and may do the same with T1R receptors, suggesting that RGS21 may play a role in sweet and bitter taste transduction processes.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RGS21
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene RGS21
Gene Accession No. Q2M5E4
Gene Alias EG624910; regulator of G-protein signaling 21; regulator of G-protein signalling 21; RGS21
Gene Symbols RGS21
Host Species Rabbit
Immunogen A synthesized peptide derived from human RGS21(Accession Q2M5E4), corresponding to amino acid residues M1-E49.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 100361166, 431704, 624910
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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