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Invitrogen™ RGS22 Polyclonal Antibody
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Catalog No. PIPA534426
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100 μg
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Catalog No. Quantity
PIPA534426 100 μg
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Catalog No. PIPA534426 Supplier Invitrogen™ Supplier No. PA534426
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Description

Rabbit Polyclonal Antibody

A suggested positive control is Jurkat cell lysate. PA5-34426 can be used with blocking peptide PEP-1468.

Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RGS22
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene RGS22
Gene Accession No. Q8NE09
Gene Alias CT145; PRTD-NY2; Regulator of G-protein signaling 22; regulator of G-protein signalling 22; RGD1565493; Rgs22
Gene Symbols RGS22
Host Species Rabbit
Immunogen A 19 amino acid synthetic peptide near the amino terminus of human RGS22.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26166, 500853
Target Species Human, Rat
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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