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Invitrogen™ RGS22 Polyclonal Antibody
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Catalog No. PIPA5104095
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100 μL
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PIPA5104095 100 μL
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Catalog No. PIPA5104095 Supplier Invitrogen™ Supplier No. PA5104095
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total RGS22.

Regulator of G-protein signaling (RGS) proteins contain an 120 amino acid conserved domain, termed the RGS domain, that acts as a GTPase-activating protein that acts to reduce the signal transmitted by the receptor-activated G-alpha subunit. RGS22 is a recently identified member of this family that localizes to the testis and can interact with guanine nucleotide binding proteins alpha 11, 12, and 13 (GNA11, GNA12, and GNA13). While RGS22 has been postulated to play a role in spermiogenesis in the testis, it is also expressed in several cancer cell lines with an epithelial origin and associated with cancer metastasis. Its overexpression in a highly metastatic cancer causes a decrease in cell migration and a reduction of the invasive potential of the cells, suggesting that RGS22 may be a potential prognostic biomarker for metastasis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RGS22
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene RGS22
Gene Accession No. G3UYX5, Q8NE09
Gene Alias CT145; PRTD-NY2; Regulator of G-protein signaling 22; regulator of G-protein signalling 22; RGD1565493; Rgs22
Gene Symbols RGS22
Host Species Rabbit
Immunogen A synthesized peptide derived from human RGS22(Accession Q8NE09), corresponding to amino acid residues R551-K601.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26166, 500853, 626596
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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