Invitrogen™ RHBDD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520860

Catalog No. PIPA520860

Description

A suggested positive control is K562 cell lysate. PA5-20860 can be used with blocking peptide PEP-0974.

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.

Specifications

• Antigen: RHBDD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RHBDD1
• Gene Alias: 4930418P06Rik; HSD50; HSD-50; mRHBDD1; MSD50; MSD-50; RGD1306477; RHBDD1; Rhbdl4; rhomboid domain containing 1; rhomboid domain-containing protein 1; Rhomboid-like protein 4; rhomboid-related protein 4; rRHBDD1; RRP4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 76867, 84236
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8BHC7, Q8TEB9
• Gene Symbols: RHBDD1
• Immunogen: A 14 amino acid peptide from near the carboxy terminus of human RHBDD1.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG