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Invitrogen™ RHBDD1 Polyclonal Antibody
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Catalog No. PIPA520860
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100 μg
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Catalog No. Quantity
PIPA520860 100 μg
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Catalog No. PIPA520860 Supplier Invitrogen™ Supplier No. PA520860
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Description

Rabbit Polyclonal Antibody

A suggested positive control is K562 cell lysate. PA5-20860 can be used with blocking peptide PEP-0974.

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RHBDD1
Applications Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene RHBDD1
Gene Accession No. Q8BHC7, Q8TEB9
Gene Alias 4930418P06Rik; HSD50; HSD-50; mRHBDD1; MSD50; MSD-50; RGD1306477; RHBDD1; Rhbdl4; rhomboid domain containing 1; rhomboid domain-containing protein 1; Rhomboid-like protein 4; rhomboid-related protein 4; rRHBDD1; RRP4
Gene Symbols RHBDD1
Host Species Rabbit
Immunogen A 14 amino acid peptide from near the carboxy terminus of human RHBDD1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 76867, 84236
Target Species Human, Mouse
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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