Invitrogen™ RHBDD1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA553102

Catalog No. PIPA553102

Description

Immunogen sequence: PLKKIMEACA GGFSSSVGYP GRQYYFNSSG SSGYQDYYPH GRPDHYEEAP RNYDTYTAGL SEEEQLERAL QASLWDRGNT RNSPPPYGFH LSPEEMRRQR LHRFD Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 73%.

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.

Specifications

• Antigen: RHBDD1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RHBDD1
• Gene Alias: 4930418P06Rik; HSD50; HSD-50; mRHBDD1; MSD50; MSD-50; RGD1306477; RHBDD1; Rhbdl4; rhomboid domain containing 1; rhomboid domain-containing protein 1; Rhomboid-like protein 4; rhomboid-related protein 4; rRHBDD1; RRP4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84236
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8TEB9
• Gene Symbols: RHBDD1
• Immunogen: Recombinant protein corresponding to Human RHBDD1. Recombinant protein control fragment (Product #RP-90982).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG