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Invitrogen™ RHBDD1 Polyclonal Antibody
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Catalog No. PIPA553102
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100 μL
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PIPA553102 100 μL
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Catalog No. PIPA553102 Supplier Invitrogen™ Supplier No. PA553102
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: PLKKIMEACA GGFSSSVGYP GRQYYFNSSG SSGYQDYYPH GRPDHYEEAP RNYDTYTAGL SEEEQLERAL QASLWDRGNT RNSPPPYGFH LSPEEMRRQR LHRFD Highest antigen sequence identity to the following orthologs: Mouse - 70%, Rat - 73%.

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD1 is highly expressed in the testis and is involved in the cleavage of BIK, a proapoptotic member of the Bcl-2 family. Overexpression or suppression by RNAi of RHBDD1 in 293 cells will reduce or enhance BIK-mediated apoptosis, respectively, demonstrating that RHBDD1 modulates BIK-mediated apoptotic activity. In GC-1 cells, a spermatogonia cell line that can differentiate into spermatids within the seminiferous tubules, suppression of RHBDD1 expression by RNAi caused the cells to lose the ability to survive and differentiate in mouse seminiferous tubules, suggesting that RHBDD1 may be associated with mammalian spermatogenesis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RHBDD1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RHBDD1
Gene Accession No. Q8TEB9
Gene Alias 4930418P06Rik; HSD50; HSD-50; mRHBDD1; MSD50; MSD-50; RGD1306477; RHBDD1; Rhbdl4; rhomboid domain containing 1; rhomboid domain-containing protein 1; Rhomboid-like protein 4; rhomboid-related protein 4; rRHBDD1; RRP4
Gene Symbols RHBDD1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RHBDD1. Recombinant protein control fragment (Product #RP-90982).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84236
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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