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Invitrogen™ RHBDD3 Polyclonal Antibody
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Catalog No. PIPA560571
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100 μL
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PIPA560571 100 μL
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Catalog No. PIPA560571 Supplier Invitrogen™ Supplier No. PA560571
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HWEDSALPPP SLRPVQPTWE GSSEAGLDWA GASFSPGTPM WAALDEQMLQ EGIQASLLDG PAQEPQSAPW LSKSSVSSL Highest antigen sequence identity to the following orthologs: Mouse - 66%, Rat - 62%.

The Rhomboid family of proteins is made up of several widely conserved polytopic membrane serine proteases that play roles in growth and development. RHBDD3 was initially identified as a novel pituitary tumor apoptosis gene (PTAG) whose expression was reduced in certain pituitary adenomas. Overexpression of RHBDD3 in AtT20 cells showed an increase in apoptotic activity and caspase activation in response to bromocriptine, and apoptosis-inducing dopamine D2 analog, suggesting that reactivation of RHBDD3 in tumors may be a therapeutically useful tool. Later experiments also showed that RHBDD3 expression is also reduced in several primary colorectal tumors, indicating that loss of RHBDD3 contributes to a blunted apoptotic response and probably predisposes cells towards malignant transformation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RHBDD3
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RHBDD3
Gene Accession No. Q9Y3P4
Gene Alias C22orf3; CTA-984G1.4; HS984G1A; pituitary tumor apoptosis; pituitary-derived proapoptotic; PTAG; RGD1311827; Rhbdd3; rhomboid domain containing 3; rhomboid domain-containing protein 3
Gene Symbols RHBDD3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RHBDD3. Recombinant protein control fragment (Product #RP-99855).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 25807
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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