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Invitrogen™ RHD Chimeric Recombinant Rabbit Monoclonal Antibody (D7C2)
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Catalog No. PIMA548188
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200 μg
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PIMA548188 200 μg
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Catalog No. PIMA548188 Supplier Invitrogen™ Supplier No. MA548188
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Description

Rabbit Recombinant Monoclonal Antibody

RHD Chimeric Recombinant Monoclonal Antibody for ICC/IF, Flow

The Rhesus (Rh) blood group system represents one of the most complex and important systems in humans. Two highly homologous genes RHD and RHCE (collectively referred to as RH30 or RHCED) encode the antigens of the Rh blood group system (1-4). These tightly linked genes map to human chromosomal position 1p34.1-1p36. The RHD gene, which is commonly deleted from a large segment of the population, encodes the most potent blood group immunogen, the D antigen (2,5). Rh incompatibility between maternal and fetal blood types results in hemolytic disease of the newborn (HDN), which often results in fetal death (1,2,6). The RHCE gene exists in four allelic forms, and each allele determines the expression of two antigens in Ce, ce, cE, or CE combinations (2,4,5). The RHCED antigens exist as integral membrane proteins with contain 12-transmembrane helices, and maintain erythrocyte membrane integrity. The presentation of the Rh antigenic activity requires the formation of a complex between the RHCED antigens and RHAG (RH50).
TRUSTED_SUSTAINABILITY

Specifications

Antigen RHD Chimeric
Applications Flow Cytometry, Immunocytochemistry
Classification Recombinant Monoclonal
Clone D7C2
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene RHD
Gene Accession No. Q02161
Gene Alias blood group antigen D; blood group protein RHD; blood group Rh(D) polypeptide; CD240D; D antigen (DCS); DIIIc; Erythrocyte membrane glycoprotein Rh30; Rh; Rh blood group antigen Evans; Rh blood group D antigen; Rh blood group protein; Rh blood group, D anitgen; Rh blood group, D antigen; RH polypeptide 2; Rh30; Rh4; Rhced; RHD; RhD blood group antigen; RhD polypeptide; RhDCw; RHDel; RHDVA(TT); Rhesus blood group CE and D; Rhesus blood group D antigen allele DIII type 7; rhesus D antigen; Rhesus system D polypeptide; RhII; RhK562-II; Rhl1; Rh-like polypeptide; RhPI; RHPII; RHXIII; truncated rhesus blood group D antigen; truncated rhesus D
Gene Symbols RHD
Host Species Rabbit
Immunogen A Rh- volunteer blood donor (r/r) was injected with 5ml of Rh+ erythrocytes (R1/r) and the peripheral lymphocytes were isolated and transformed with 1 ml of culture supernatant of the EBV marmoset B96-8 cell line.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6007
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG λ
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