Invitrogen™ RHD Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110293

Catalog No. PIPA5110293

Description

Immunogen sequence: LGNLRMVISN IFNTDYHMNM MHIYVFAAYF GLSVAWCLPK PLPEGTEDKD QTATIPSLSA MLGALFLWMF WPSFNSALLR SPIERKNAVF NTYYAVAVSV V.

The Rhesus (Rh) blood group system represents one of the most complex and important systems in humans. Two highly homologous genes RHD and RHCE (collectively referred to as RH30 or RHCED) encode the antigens of the Rh blood group system (1-4). These tightly linked genes map to human chromosomal position 1p34.1-1p36. The RHD gene, which is commonly deleted from a large segment of the population, encodes the most potent blood group immunogen, the D antigen (2,5). Rh incompatibility between maternal and fetal blood types results in hemolytic disease of the newborn (HDN), which often results in fetal death (1,2,6). The RHCE gene exists in four allelic forms, and each allele determines the expression of two antigens in Ce, ce, cE, or CE combinations (2,4,5). The RHCED antigens exist as integral membrane proteins with contain 12-transmembrane helices, and maintain erythrocyte membrane integrity. The presentation of the Rh antigenic activity requires the formation of a complex between the RHCED antigens and RHAG (RH50).

Specifications

• Antigen: RHD
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RHD
• Gene Alias: blood group antigen D; blood group protein RHD; blood group Rh(D) polypeptide; CD240D; D antigen (DCS); DIIIc; Erythrocyte membrane glycoprotein Rh30; Rh; Rh blood group antigen Evans; Rh blood group D antigen; Rh blood group protein; Rh blood group, D anitgen; Rh blood group, D antigen; RH polypeptide 2; Rh30; Rh4; Rhced; RHD; RhD blood group antigen; RhD polypeptide; RhDCw; RHDel; RHDVA(TT); Rhesus blood group CE and D; Rhesus blood group D antigen allele DIII type 7; rhesus D antigen; Rhesus system D polypeptide; RhII; RhK562-II; Rhl1; Rh-like polypeptide; RhPI; RHPII; RHXIII; truncated rhesus blood group D antigen; truncated rhesus D
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 19746, 60414
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.13 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O88298, Q8CF94
• Gene Symbols: RHD
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 150-250 of human RHD (NP_001121163.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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