Invitrogen™ RhoB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA577865

Catalog No. PIPA577865

Description

Positive Control: U87-MG, mouse brain, rat brain Predicted Reactivity: Xenopus laevis (90%), Dog (99%), Pig (100%), Chicken (97%), Sheep (100%), Rhesus Monkey (89%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.

Specifications

• Antigen: RhoB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RHOB
• Gene Alias: AA017882; Aplysia RAS-related homolog 6; aplysia ras-related homolog B; Arh6; Arhb; h6; MST081; MSTP081; oncogene RHO H6; ras homolog B; ras homolog family member B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho; rho cDNA clone 6; rhoB; RHOH6; Rho-related GTP-binding protein RhoB
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11852, 388, 64373
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.34 mg/mL
• Formulation: 0.1M Tris glycine with 10% glycerol, 0.1M glycine and 0.01% thimerosal; pH 7
• Gene Accession No.: P62745, P62746, P62747
• Gene Symbols: RHOB
• Immunogen: Recombinant protein encompassing a sequence within the center region of human RhoB. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG