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Invitrogen™ RhoB Polyclonal Antibody
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Catalog No. PIPA577865
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100 μL
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Catalog No. Quantity
PIPA577865 100 μL
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Catalog No. PIPA577865 Supplier Invitrogen™ Supplier No. PA577865
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Description

Rabbit Polyclonal Antibody

Positive Control: U87-MG, mouse brain, rat brain Predicted Reactivity: Xenopus laevis (90%), Dog (99%), Pig (100%), Chicken (97%), Sheep (100%), Rhesus Monkey (89%), Bovine (100%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RhoB
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.34 mg/mL
Conjugate Unconjugated
Formulation 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene RHOB
Gene Accession No. P62745, P62746, P62747
Gene Alias AA017882; Aplysia RAS-related homolog 6; aplysia ras-related homolog B; Arh6; Arhb; h6; MST081; MSTP081; oncogene RHO H6; ras homolog B; ras homolog family member B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho; rho cDNA clone 6; rhoB; RHOH6; Rho-related GTP-binding protein RhoB
Gene Symbols RHOB
Host Species Rabbit
Immunogen Recombinant protein encompassing a sequence within the center region of human RhoB. The exact sequence is proprietary.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11852, 388, 64373
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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