Invitrogen™ RhoB Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA588525

Catalog No. PIPA588525

Description

Immunogen sequence: MAAIRKKLVV VGDGACGKTC LLIVFSKDEF PEVYVPTVFE NYVADIEVDG KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWV PEVKHFCPNV PIILVANKKD LRSDEHVRTE LARMKQEPVR TDDGRAMAVR IQAYDYLECS AKTKEGVREV FETATRAALQ KRYGSQNGCI NCCKVL; Positive Samples: Mouse brain, Rat brain; Cellular Location: Cell membrane, Cleavage furrow, Late endosome membrane, Lipid-anchor, Nucleus.

Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.

Specifications

• Antigen: RhoB
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RHOB
• Gene Alias: AA017882; Aplysia RAS-related homolog 6; aplysia ras-related homolog B; Arh6; Arhb; h6; MST081; MSTP081; oncogene RHO H6; ras homolog B; ras homolog family member B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho; rho cDNA clone 6; rhoB; RHOH6; Rho-related GTP-binding protein RhoB
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11852, 64373
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.26 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P62746, P62747
• Gene Symbols: RHOB
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-196 of human RhoB (NP_0040311).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG