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Invitrogen™ RhoB Polyclonal Antibody
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Catalog No. PIPA591839
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100 μL
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PIPA591839 100 μL
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Catalog No. PIPA591839 Supplier Invitrogen™ Supplier No. PA591839
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Description

Rabbit Polyclonal Antibody

Positive Samples: Mouse brain; Cellular Location: Cell membrane, Cleavage furrow, Late endosome membrane, Lipid-anchor, Nucleus Immunogen sequence: VPEVKHFCPN VPIILVANKK DLRSDEHVRT ELARMKQEPV RTDDGRAMAV RIQAYDYLEC SAKTKEGVRE VFETATRAAL QKRYGSQNGC I.

Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RhoB
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.68 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene RHOB
Gene Accession No. P62745, P62746, P62747
Gene Alias AA017882; Aplysia RAS-related homolog 6; aplysia ras-related homolog B; Arh6; Arhb; h6; MST081; MSTP081; oncogene RHO H6; ras homolog B; ras homolog family member B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho; rho cDNA clone 6; rhoB; RHOH6; Rho-related GTP-binding protein RhoB
Gene Symbols RHOB
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 100-190 of human RhoB (NP_0040311).
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11852, 388, 64373
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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