Invitrogen™ RhoB Recombinant Rabbit Monoclonal Antibody (3B10K10)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA551248

Catalog No. FEMA551248

Description

Immunogen sequence: RPLSYPDTDV ILMCFSVDSP DSLENIPEKW VPEVKHFCPN VPIILVANKK DLRSDEHVRT ELARMKQEPV RTDDGRAMAV R.

Rho-related GTP-binding protein (RhoB) mediates apoptosis in neoplastically transformed cells after DNA damage. While not essential for development, it does affect cell adhesion and growth factor signaling in transformed cells. RhoB targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a tumor supressor - deletion of RhoB causes tumor formation.

Specifications

• Antigen: RhoB
• Classification: Recombinant Monoclonal
• Concentration: 0.07 mg/mL
• Formulation: PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
• Gene Accession No.: P62745, P62746, P62747
• Gene Symbols: RHOB
• Immunogen: A synthetic peptide corresponding to a sequence within amino acids 70-150 of human RhoB (NP_004031.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Format: Liquid

• Applications: ELISA, Western Blot
• Clone: 3B10K10
• Conjugate: Unconjugated
• Gene: RHOB
• Gene Alias: AA017882; Aplysia RAS-related homolog 6; aplysia ras-related homolog B; Arh6; Arhb; h6; MST081; MSTP081; oncogene RHO H6; ras homolog B; ras homolog family member B; ras homolog gene family, member AB; ras homolog gene family, member B; Rho; rho cDNA clone 6; rhoB; RHOH6; Rho-related GTP-binding protein RhoB
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11852, 388, 64373
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid
• Isotype: IgG