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Invitrogen™ RhoGAP Polyclonal Antibody
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Catalog No. PIPA582344
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100 μL
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PIPA582344 100 μL
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Catalog No. PIPA582344 Supplier Invitrogen™ Supplier No. PA582344
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DFDQYNELHL PAVILKTFLR ELPEPLLTFD LYPHVVGFLN IDESQRVPAT LQVLQTLPEE NYQVLRFLTA FLVQISAHSD QNKMTNTNLA VVFGPNLLWA KDAAITLKAI NPINTFTKFL LDHQGELF Highest antigen sequence indentity to the following orthologs: Rat - 89%, Mouse - 96%.

The p190 RhoGAP protein is associated with p120 RasGAP in growth-factor stimulated and tyrosine kinase transformed cells. It functions as a GTPase - activating protein (GAP) for Rho and Rac family proteins, which are involved in regulating cytoskeletal actin and membrane ruffling. The antibody appears to couple signal transduction via Ras and Rho through its association with RasGAP. The presence of two adjacent SH2 domains in the p21 RAS GAP indicates that GAP might interact directly with tyrosine kinases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RhoGAP
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ARHGAP1
Gene Accession No. Q07960, Q5FWK3
Gene Alias ARHGAP1; ARHGAP5; B230365D05Rik; C76222; CDC42 GTPase-activating protein; CDC42GAP; GFI2; growth factor independent 2; GTPase-activating protein rhoGAP; GTPase-activating protein rhoOGAP; GTPase-activating protein, Rho, 1; LOC512817 protein; p100 RasGAP-associated p105 protein; p105 RhoGAP; p190-B; p190BRhoGAP; p50rhoGAP; p50-RhoGAP; Rho GTPase activating protein 1; Rho GTPase activating protein 5; rho GTPase-activating protein 1; Rho GTPase-activating protein 5; RHOGAP; RHOGAP1; RHOGAP5; rho-related small GTPase protein activator; Rho-type GTPase-activating protein 1; rho-type GTPase-activating protein 5
Gene Symbols ARHGAP1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ARHGAP1. Recombinant protein control fragment (Product #RP-102446).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 228359, 311193, 392
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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