Invitrogen™ Rhotekin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA529931

Catalog No. PIPA529931

Description

Recommended positive controls: 293T, A431, Jurkat, Raji, mouse brain, NCI-H929, human Rhotekin-transfected 293T. Predicted reactivity: Mouse (93%), Rat (96%), Rhesus Monkey (99%), Bovine (94%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

This gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms.

Specifications

• Antigen: Rhotekin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RTKN
• Gene Alias: hypothetical protein LOC539691; RGD:727874}; rhotekin; RTKN; rtkn {ECO:0000312; RTKN1
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 20166, 6242
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.54 mg/mL
• Formulation: 0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q8C6B2, Q9BST9
• Gene Symbols: RTKN
• Immunogen: Recombinant protein fragment corresponding to a region within amino acids 1 and 141 of Human Rhotekin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov