Invitrogen™ RhoV Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA562781

Catalog No. PIPA562781

Description

Immunogen sequence: KEVFDSAILS AIEHKARLEK KLNAKGVRTL SRCRWKKFFC FV Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.

The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. Rho V (ras homolog gene family, member V), also known as Rho GTPase-like protein ARHV, CHP or WRCH2 (Wnt-1 responsive Cdc42 homolog 2), is a 236 amino acid protein that controls the actin cytoskeleton through activation of the JNK pathway. A member of the Rho family and small GTPase superfamily, Rho V functions as a lipid anchor at the cytoplasmic side of the cell membrane and is expressed in placenta, pancreas and fetal brain. Rho V is implicated in cell transformation and is encoded by a gene located on human chromosome 15, which houses over 700 genes and comprises nearly 3% of the human genome. Angelman syndrome, Prader-Willi syndrome, Tay-Sachs disease and Marfan syndrome are all associated with defects in chromosome 15-localized genes.

Specifications

• Antigen: RhoV
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rhov
• Gene Alias: A030005A06Rik; ARHV; calcium binding protein p22; CDC42-like GTPase 2; CHP; GTP-binding protein-like 2; ras homolog family member V; ras homolog gene family, member V; RGD:628824}; rho family GTPase Chp; Rho GTPase-like protein ARHV; rho-related GTP-binding protein RhoV; RHOV; rhov {ECO:0000312; Wnt-1 regulated Cdc42 homolog 2; Wnt-1 responsive Cdc42 homolog 2; WRCH1-related GTPase; WRCH2; WRCH-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 171177
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q96L33
• Gene Symbols: Rhov
• Immunogen: Recombinant protein corresponding to Human RhoV. Recombinant protein control fragment (Product #RP-104211).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG