Invitrogen™ RIC8A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5110295

Catalog No. PIPA5110295

Description

Immunogen sequence: DVRTRPEVGE MLRNKLVRLM THLDTDVKRV AAEFLFVLCS ESVPRFIKYT GYGNAAGLLA ARGLMAGGRP EGQYSEDEDT DTDEYKEAKA SINPVTGRVE EKPPNPMEGM TEEQKEHEAM KLVTMFDKLS RNRVIQPMGM SPRGHLTSLQ DAMCETMEQQ LSSDPDSDPD.

Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex. Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.

Specifications

• Antigen: RIC8A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RIC8A
• Gene Alias: AI114950; heterotrimeric G protein guanine nucleotide exchange factor Ric-8A; MGC104517; MGC131931; MGC148073; MGC148074; Protein Ric-8A; resistance to inhibitors of cholinesterase 8 homolog; resistance to inhibitors of cholinesterase 8 homolog (C. elegans); resistance to inhibitors of cholinesterase 8 homolog A; resistance to inhibitors of cholinesterase 8A; Ric8; RIC-8; RIC8 guanine nucleotide exchange factor A; RIC8 protein; Ric8a; Ric-8A; synembryn; synembryn-A
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101489, 293614, 60626
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.45 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: Q3TIR3, Q80ZG1, Q9NPQ8
• Gene Symbols: RIC8A
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 362-531 of human RIC8A (NP_001273063.1).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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