Invitrogen™ RICH2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558550

Catalog No. PIPA558550

Description

Immunogen sequence: STPSPYGLSY PQGYSLASGQ LSPAAAPPLA SPSVFTSTLS KSRPTPKPRQ RPTLPPPQPP TVNLSASSPQ STEAPMLDGM SPGESMSTDL VHFDIPSIHI ELGSTLRLSP LEHMRRHSVT DKRDSE Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. [UniProt].

Specifications

• Antigen: RICH2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ARHGAP44
• Gene Alias: ARHGAP44; KIAA0672; NPC-A-10; Rho GTPase activating protein 44; rho GTPase-activating protein 44; rho GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; Rho-type GTPase-activating protein RICH2; RICH2; RICH-2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9912
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 0.3 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q17R89
• Gene Symbols: ARHGAP44
• Immunogen: Recombinant protein corresponding to Human RICH2. Recombinant protein control fragment (Product #RP-102315).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG