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Invitrogen™ RICH2 Polyclonal Antibody
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Catalog No. PIPA5121092
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100 μL
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PIPA5121092 100 μL
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Catalog No. PIPA5121092 Supplier Invitrogen™ Supplier No. PA5121092
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Description

Rabbit Polyclonal Antibody

Positive test controls include: MCF7, 293T, Mouse brain, Mouse heart, Mouse lung, Rat heart, Rat brain. The target is usually found in the following locations: Cell junction, Cell projection, Recycling endosome, dendritic spine, synapse. Immunogen sequence: MADQSAGQPS PVSLSPTPPS TPSPYGLSYP QGYSLASGQL SPAAAPPLAS PSVFTSTLSK SRPTPKPRQR PTLPPPQPPT VNLSASSPQS TEAPMLDGMS PGESMST.

GTPase-activating protein (GAP) that stimulates the GTPase activity of Rho-type GTPases. Thereby, controls Rho-type GTPases cycling between their active GTP-bound and inactive GDP-bound states. Acts as a GAP at least for CDC42 and RAC1 (PubMed:11431473). In neurons, is involved in dendritic spine formation and synaptic plasticity in a specific RAC1-GAP activity. Limits the initiation of exploratory dendritic filopodia. Recruited to actin-patches that seed filopodia, binds specifically to plasma membrane sections that are deformed inward by acto-myosin mediated contractile forces. Acts through GAP activity on RAC1 to reduce actin polymerization necessary for filopodia formation. In association with SHANK3, promotes GRIA1 exocytosis from recycling endosomes and spine morphological changes associated to long-term potentiation. [UniProt].
TRUSTED_SUSTAINABILITY

Specifications

Antigen RICH2
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.75 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ARHGAP44
Gene Accession No. F1LQX4, Q17R89, Q5SSM3
Gene Alias ARHGAP44; KIAA0672; NPC-A-10; Rho GTPase activating protein 44; rho GTPase-activating protein 44; rho GTPase-activating protein RICH2; RhoGAP interacting with CIP4 homologs protein 2; Rho-type GTPase-activating protein RICH2; RICH2; RICH-2
Gene Symbols ARHGAP44
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 666-772 of human ARHGAP44 (NP_055674.4).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 216831, 303222, 9912
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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