Invitrogen™ RIM2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA584724

Catalog No. PIPA584724

Description

Immunogen sequence: MDIEERNRQM KINKYKQVAG SDPRLEQDYH SKYRSGWDPH RGADNVSTKS S.

Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. Rim1 and Rim2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like Rim1, Rim2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.

Specifications

• Antigen: RIM2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Rims2
• Gene Alias: 2810036I15Rik; AW048769; KIAA0751; mKIAA0751; Nim2; non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; OBOE; Rab3 interacting protein 1; Rab3 interacting protein 2; RAB3 interacting protein 3; Rab-3-interacting molecule 2; rab3-interacting molecule 2; Rab3-interacting protein; rab-3-interacting protein 2; rab3-interacting protein 2; Rab-3-interacting protein 3; Rab3ip2; RAB3IP3; regulating synaptic membrane exocytosis 2; regulating synaptic membrane exocytosis protein 2; RIM 2; Rim2; RIM2 (CT); Rim2(+40A); Rim2(+44A); Rim2(+4A); Rims2; Serg2; synaptic exocytosis regulator 2; synaptotagmin 3, related sequence; Syt3-rs
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9699
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin)
• Concentration: 0.2 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q9UQ26
• Gene Symbols: Rims2
• Immunogen: Recombinant protein corresponding to Human RIMS2. Recombinant protein control fragment (Product #RP-107501).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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