Invitrogen™ RIM3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520475

Catalog No. PIPA520475

Description

A suggested positive control is human brain tissue lysate. PA5-20475 can be used with blocking peptide PEP-0595.

Rab3-interacting molecules (RIMs) are synaptic proteins are synaptic proteins necessary for neural transmission and plasticity. While both Rim1 and Rim 2 are thought to be effector proteins for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner, less is known of Rim3. Expression of Rim3 in PC12 cells induced a significant increase in calcium-triggered exocytosis, with no appreciable change in the baseline release, suggesting that it plays a role in the regulation of exocytosis. Rim3 protein localizes primarily to neuronal dendrites and the postsynaptic densities, as opposed to Rim1 which is found in presynapse locations, indicating that Rim3 may contribute to synapse transmission and plasticity.

Specifications

• Antigen: RIM3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RIMS3
• Gene Alias: A730060M23Rik; KIAA0237; mKIAA0237; Nim2; NIM3; Rab-3 interacting molecule 3; rab-3-interacting molecule 3; regulating synaptic membrane exocytosis 3; regulating synaptic membrane exocytosis protein 3; RIM 3; RIM3; RIM3 gamma; Rims3; RP4-739H11.2; si:ch211-239d6.1
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 242662, 9783
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q80U57, Q9UJD0
• Gene Symbols: RIMS3
• Immunogen: A 17 amino acid peptide from near the amino terminus of human Rim3.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov