RIN1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Manufacturer: Proteintech Group Inc 163881AP
DescriptionRit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.
|PBS with 50% glycerol and 0.02% sodium azide; pH 7.3|
|P97680, Q13671, Q921Q7|
|Ras and Rab interactor 1, Ras inhibitor JC99, RIN1|
|207119, 225870, 9610|
|Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot|
|RIN1 Fusion Protein Ag9451|
|Antigen Affinity Chromatography|
|Human, Mouse, Rat|
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