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Invitrogen™ RIP1 Monoclonal Antibody (CL11368)
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Catalog No. PIMA544166
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Quantity:
100 μL
Catalog No. Quantity
PIMA544166 100 μL
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Catalog No. PIMA544166

Supplier: Invitrogen™ MA544166

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Description

Mouse Monoclonal Antibody

The antibody solution should be gently mixed before use. Optimal concentrations and conditions for each application should be determined by the user. Immunogen sequence: KEYSNENAVV KRMQSLQLDC VAVPSSRSNS ATEQPGSLHS SQGLGMGPVE ESWFAPSLEH PQEENEPSLQ SKLQDEANYH LYGSRMDRQT KQQPRQNVAY NREEERRRRV SHDPFAQQRP YENFQNTEGK GTAYSSAASH GNAV Highest antigen sequence indentity to the following orthologs: Rat - 67%, Mouse - 63%.

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RIP1
Applications Western Blot
Classification Monoclonal
Clone CL11368
Concentration 0.95 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RIPK1
Gene Accession No. Q13546
Gene Alias cell death protein RIP; D330015H01Rik; FLJ39204; OTTHUMP00000015955; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting serine/threonine kinase 1; receptor-interacting protein 1; receptor-interacting protein kinase 1; receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; RIP1; RIP-1; RIP1 (CT); RIPK1; serine/threonine-protein kinase RIP
Gene Symbols RIPK1
Host Species Mouse
Immunogen Recombinant protein fragment of Human RIPK1 (Product #RP-91447)
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8737
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

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