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Invitrogen™ RIP1 Recombinant Rabbit Monoclonal Antibody (HL2249)
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Catalog No. FEMA550455
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100 μL
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FEMA550455 100 μL
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Catalog No. FEMA550455 Supplier Invitrogen™ Supplier No. MA550455
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Description

Rabbit Recombinant Monoclonal Antibody

RIP1 Recombinant Monoclonal Antibody for Western Blot, ICC/IF

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at 'Ser-728' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via 'Lys-63'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RIP1
Applications Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone HL2249
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene RIPK1
Gene Accession No. Q13546
Gene Alias cell death protein RIP; D330015H01Rik; FLJ39204; OTTHUMP00000015955; receptor (TNFRSF)-interacting serine-threonine kinase 1; receptor interacting serine/threonine kinase 1; receptor-interacting protein 1; receptor-interacting protein kinase 1; receptor-interacting serine/threonine-protein kinase 1; Rinp; RIP; RIP1; RIP-1; RIP1 (CT); RIPK1; serine/threonine-protein kinase RIP
Gene Symbols RIPK1
Host Species Rabbit
Immunogen Recombinant fragmemt of human RIP.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 8737
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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