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  5. Tocris Bioscience™ RIPA 56

Tocris Bioscience™ RIPA 56
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Catalog No. 733950
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Catalog No. Quantity
73-395-0 50 mg
73-391-0 10 mg
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Catalog No. 73-395-0 Supplier Tocris Bioscience™ Supplier No. 7339/50
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Description

Potent and metabolically stable RIP1 kinase inhibitor

RIPA 56 is a potent and metabolically stable receptor-interacting protein kinase 1 (RIPK1) inhibitor (EC50 = 13 nM). RIPA-56 shows no inhibition of RIP3 kinase at 10 μM . RIPA 56 blocks necroptosis and aging of the mouse male reproductive system. RIPA 56 reduces tumor necrosis factor α (TNFα)-induced mortality and multi-organ damage in a mouse model of systemic inflammatory response syndrome (SIRS). RIPA 56 is orally bioavailable.

Specifications

Chemical Name or Material N-Hydroxy-2,2-dimethyl-N-(phenylmethyl)butanamide
CAS 1956370-21-0
Quantity 50 mg
Target RIP Kinase Inhibitors
Molecular Formula C13H19NO2
Purity 0.98
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