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Tocris Bioscience™ RIPGBM
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Catalog No. 689250
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Catalog No. Quantity
68-925-0 50 mg
68-921-0 10 mg
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Catalog No. 68-925-0 Supplier Tocris Bioscience™ Supplier No. 6892/50
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Description

RIPK2 modulator; pro-drug of cRIPGM; orally bioavailable and brain penetrant

RIPGBM is a RIPK2 modulator, pro-drug of cRIPGM. cRIPGM binds RIPK2 (apparent Kd = 2.3 μM). Selectively induces apoptosis in glioblastoma multiforme cancer stem cell lines (EC50 is <500 nM). Five-fold selective for CSCs compared with control cell types. Reduces the formation of a prosurvival RIPK2/ TAK1 complex and increases the formation of a proapoptotic RIPK2/caspase 1 complex. Inhibits tumor formation and growth in vivo. Orally bioavailable and brain penetrant.

Specifications

Chemical Name or Material N-[1,4-Dihydro-1,4-dioxo-3-[(phenylmethyl)amino]-2-naphthalenyl]-N-[(4-fluorophenyl)methyl]acetamide
CAS 355406-76-7
Quantity 50 mg
Target RIP Kinase Inhibitors
Molecular Formula C26H21FN2O3
Formula Weight 7272
Purity 98%
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