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RIPK1 Mouse anti-Human, Clone: OTI2F1, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF800307

Encompass_Preferred

Catalog No. 50-166-5014


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at ′Ser-728′ in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via ′Lys-63′-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecules. Polyubiquitinated protein binds to IKBKG/NEMO, the regulatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellular RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particular, forms a necrosis-inducing complex.
Specifications

Specifications

RIPK1
Monoclonal
Unconjugated
RIPK1
RIP, RIP-1, RIP1
Mouse
Affinity Chromatography
RUO
8737
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI2F1
PBS with 8% trehalose and no preservative; pH 7.3
Q13546
RIPK1
Human recombit protein fragment corresponding to amino acids 133-422 of human RIPK1 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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