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RIPK3 Mouse anti-Human, Clone: OTI2C11, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF803101

Encompass_Preferred

Catalog No. 50-166-6330


May include imposed supplier surcharges.
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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.
Specifications

Specifications

RIPK3
Monoclonal
Unconjugated
RIPK3
RIP3
Mouse
Affinity Chromatography
RUO
11035
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Western Blot
OTI2C11
PBS with 8% trehalose and no preservative; pH 7.3
Q9Y572
RIPK3
Human recombit protein fragment corresponding to amino acids 233-518 of human RIPK3 produced in E.coli.
100 μg
Primary
Human
Antibody
IgG1
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