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RIPK3 Mouse anti-Human, Clone: OTI2C11, lyophilized, TrueMAB™

Mouse Monoclonal Antibody
Supplier: OriGene CF803101

Description
Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO
RIP3 is a novel member of RIP Ser/Thr kinase family. It is a potent inducer of apoptosis and is an important component of TNFR1 signaling complex. RIP3 consists of an N-terminal RIP-like-Kinase domain and a unique, non-homologous C-terminus responsible for caspase activation and apoptosis induction. RIP3 is expressed in multiple tissues including hematopoietic cells and plays a functional role in the regulation of apoptosis and NF-kB signaling. It is recruited to the TNFR1 signaling complex in a RIP-dependant manner where it induces apoptosis by activating caspases and/or inhibiting TNFR1-induced NF-kB activation. RIP3 negatively regulates the TLR3-Trif-mediated NF-kB signaling pathway by competing with the binding of Trif to RIP1. The human RIP3 gene is localized in the chromosomal region 14q11.2.Specifications
RIPK3 | |
Monoclonal | |
Unconjugated | |
RIPK3 | |
RIP3 | |
Mouse | |
Affinity Chromatography | |
RUO | |
11035 | |
-20° C, Avoid Freeze/Thaw Cycles | |
Lyophilized |
Western Blot | |
OTI2C11 | |
PBS with 8% trehalose and no preservative; pH 7.3 | |
Q9Y572 | |
RIPK3 | |
Human recombit protein fragment corresponding to amino acids 233-518 of human RIPK3 produced in E.coli. | |
100 μg | |
Primary | |
Human | |
Antibody | |
IgG1 |
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