Invitrogen™ RISC Polyclonal Antibody

Catalog No.	Quantity
PIPA583448	100 μL

Catalog No. PIPA583448 Supplier Invitrogen™ Supplier No. PA583448

Description

Rabbit Polyclonal Antibody

Immunogen sequence: KPVISIVDEL LEAGINVTVY NGQLDLIVDT MGQEAWVRKL KWPELPKFSQ LKWKALYSDP KSLETSAFVK SYKNLAFYWI LKAGHMVPSD QGDMALKMMR LVTQQ Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 85%.

The RNA-induced silencing complex (RISC) is a key player in the regulation of gene expression through RNA interference (RNAi) mechanisms. It operates by utilizing small RNA molecules-such as microRNAs (miRNAs), small interfering RNAs (siRNAs), and PIWI-interacting RNAs (piRNAs)-which are processed from double-stranded RNA precursors by enzymes like Drosha and Dicer in animals, and DICER-LIKE in plants. RISC is a versatile molecular complex consisting of Argonaute proteins as its core component, which guides the complex to the target RNA by complementary base pairing. Once assembled, RISC can recruit other proteins that mediate gene silencing by degrading or inhibiting the translation of the target RNA. This post-transcriptional regulation system is integral to numerous biological processes, allowing cells to control gene expression finely and respond to endogenous and exogenous signals. The functionality of RISC in gene silencing highlights its significance in the broader context of genetic regulation and has implications in therapies that target gene expression through RNAi.

Specifications

• Antigen: RISC
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 0.1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene: SCPEP1
• Gene Accession No.: Q920A5, Q920A6, Q9HB40
• Gene Alias: 2410018F01Rik; 4833411K15Rik; AI957256; HSCP1; MSTP034; retinoid inducible serine carboxypeptidase; retinoid-inducible serine carboxypeptidase; retinoid-inducible serine caroboxypeptidase; retinoid-inducible serine caroboxypetidase; Risc; SCP1; SCPEP1; Serine carboxypeptidase 1; serine carboxypeptidase 1 precursor protein; serine caroboxypeptidase 1; UNQ265/PRO302
• Gene Symbols: SCPEP1
• Host Species: Rabbit
• Immunogen: Recombinant protein corresponding to Human SCPEP1. Recombinant protein control fragment (Product #RP-93236).
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 114861, 59342, 74617
• Target Species: Human, Mouse, Rat
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG