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Invitrogen™ RIT1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5115848

Catalog No. PIPA5115848


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Description

Description

Antibody detects endogenous levels of total RIT1.

Rit and its neuron-specific homologue, Rin, define a recently discovered subfamily of Ras-related GTPases. Rit and Rin are membrane-associated in spite of the fact that they lack a CAAX box or similar C-terminal lipidation motif. Rit and Rin display 64% amino acid sequence identity and share a unique nine amino acid effector domain (DPTIEDAYK) that is 100% conserved between the murine and human proteins. Although the effector domain sequences of Rit and Rin are very similar to that of Ras, Rit and Rin have been shown to interact with the known Ras-binding proteins RalGDS, Rlf and AF-6, but not the Raf kinases, RIN1 or the p110 subunit of PI3 kinase. For this reason, it has been suggested that Rit and Rin may play important roles in the regulation of signaling pathways distinct from those controlled by Ras.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

RIT1
Polyclonal
Unconjugated
RIT1
GTP-binding protein Rit1; GTP-binding protein Roc1; MGC125864; MGC125865; NS8; Ras like without CAAX 1; ras-like protein expressed in many tissues; Ras-like without CAAX 1; ras-like without CAAX protein 1; RGD1559874; RIBB; Ric-like, expressed in many tissues; RIT; RIT1; ROC1; si:ch211-93a2.3
Rabbit
Affinity chromatography
RUO
19769, 499652, 6016
-20°C
Liquid
Western Blot, Immunocytochemistry
1 mg/mL
PBS with 50% glycerol and 0.02% sodium azide
P70426, Q92963
RIT1
A synthesized peptide derived from human RIT1(Accession Q92963), corresponding to amino acid residues R184-T219.
100 μL
Primary
Human, Mouse, Rat
Antibody
IgG
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