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Invitrogen™ RIT2 Monoclonal Antibody (456313)
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Catalog No. PIMA524177
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Quantity:
100 μg
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Catalog No. Quantity
PIMA524177 100 μg
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Catalog No. PIMA524177 Supplier Invitrogen™ Supplier No. MA524177
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Description

Mouse Monoclonal Antibody

Reconstitute at 0.5 mg/mL in sterile PBS.

Ras-like without CAAX 2 (RIT2) is a gene located on chromosome 18q12.1, encoding a member of the Ras superfamily of small GTPases. RIT2 is primarily expressed in neuronal tissues, where it plays a crucial role in intracellular signaling pathways that regulate neuronal differentiation, survival, and plasticity. Functionally, RIT2 is involved in neurotrophic factor signaling, contributing to the maintenance and function of the nervous system. This protein interacts with various downstream effectors to influence cellular processes such as growth factor response and neuronal signaling dynamics. Alterations or mutations in RIT2 have been associated with neurological disorders, including Parkinson's disease, implicating its role in neurodegenerative processes. Research into RIT2 aims to elucidate its precise mechanisms in neural signaling and its potential as a therapeutic target for treating neurodegenerative diseases.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RIT2
Applications Immunohistochemistry, Western Blot
Classification Monoclonal
Clone 456313
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 5% trehalose and No Preservative
Gene RIT2
Gene Accession No. Q99578
Gene Alias GTP-binding protein Rit2; GTP-binding protein Roc2; Ras like without CAAX 2; RAS-like protein expressed in neuron; ras-like protein expressed in neurons; Ras-like without CAAX 1; Ras-like without CAAX 2; ras-like without CAAX protein 2; RIBA; Ric-like, expressed in neurons; RIN; Rit1; RIT2; ROC2
Gene Symbols RIT2
Host Species Mouse
Immunogen E. coli-derived recombinant human Rit2 (aa 1-217).
Purification Method Protein A/G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6014
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Lyophilized
Isotype IgG2b
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