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Invitrogen™ RKHD1 Polyclonal Antibody
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Catalog No. PIPA595905
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100 μL
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PIPA595905 100 μL
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Catalog No. PIPA595905 Supplier Invitrogen™ Supplier No. PA595905
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: AGARRSSGAG TPRHSPTLPE PGGLRLELPL SRRGAPDPVG ALSWRPPQGP VSFPGGAAFS TATSLPSSPA AAACAPLDSG ASENSRKPPS ASSAPALARE C.

Rkhd1, also known as TINO or MEX3D is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd1 binds to the AU-rich element in the 3'-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RKHD1
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.54 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Mex3d
Gene Accession No. Q3UE17
Gene Alias BC059858; bcl-2 ARE RNA binding protein; KIAA2031; MEX3; mex3 homolog D (C. elegans); mex-3 RNA binding family member D; Mex3d; MEX-3D; OK/SW-cl.4; ring finger (C3HC4 type) and KH domain containing 1; ring finger and KH domain containing 1; RING finger and KH domain-containing protein 1; RING finger protein 193; RKHD1; RNA-binding protein MEX3D; RNF193; TINO
Gene Symbols Mex3d
Host Species Rabbit
Immunogen A synthetic peptide corresponding to a sequence within amino acids 500-600 of human MEX3D (NP_9760493).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 237400
Target Species Mouse
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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