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Invitrogen™ RKHD1 Polyclonal Antibody
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Catalog No. PIPA520621
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100 μg
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Catalog No. Quantity
PIPA520621 100 μg
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Catalog No. PIPA520621 Supplier Invitrogen™ Supplier No. PA520621
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Description

Rabbit Polyclonal Antibody

A suggested positive control is MDA-MB-361 cell lysate. PA5-20621 can be used with blocking peptide PEP-0741.

Rkhd1, also known as TINO or MEX3D is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd1, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. Rkhd1 binds to the AU-rich element in the 3'-untranslated region of Bcl-2 mRNA and is thought to be a negative regulator of Bcl-2 expression. Rkhd3 and Rkhd4, but not Rkhd1, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RKHD1
Applications Immunohistochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene Mex3d
Gene Accession No. Q86XN8
Gene Alias BC059858; bcl-2 ARE RNA binding protein; KIAA2031; MEX3; mex3 homolog D (C. elegans); mex-3 RNA binding family member D; Mex3d; MEX-3D; OK/SW-cl.4; ring finger (C3HC4 type) and KH domain containing 1; ring finger and KH domain containing 1; RING finger and KH domain-containing protein 1; RING finger protein 193; RKHD1; RNA-binding protein MEX3D; RNF193; TINO
Gene Symbols Mex3d
Host Species Rabbit
Immunogen A 15 amino acid peptide from near the center of human Rkhd1.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 399664
Target Species Human
Content And Storage Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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