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Invitrogen™ RKHD2 Polyclonal Antibody
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Catalog No. PIPA559220
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100 μL
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PIPA559220 100 μL
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Catalog No. PIPA559220 Supplier Invitrogen™ Supplier No. PA559220
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: NRLADFSPTS PFSTGNFWFG DTLPSVGSED LAVDSPAFDS LPTSAQTIWT PFEPVNPLSG FGSDPSGNMK TQRRGSQPST PRLSP Highest antigen sequence identity to the following orthologs: Mouse - 99%, Rat - 100%.

Rkhd2, also known as MEX3C is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd2, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. It has been suggested that genetic variations in Rkhd2 may be associated with susceptibility to essential hypertension type 8. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RKHD2
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene MEX3C
Gene Accession No. Q5U5Q3
Gene Alias A130001D14Rik; BC035207; BM-013; mex-3 homolog C; mex3 homolog C (C. elegans); mex-3 RNA binding family member C; Mex3c; MEX-3C; MEX3C variant 1; MEX3C variant 10; MEX3C variant 11; MEX3C variant 2; MEX3C variant 3; MEX3C variant 4; MEX3C variant 5; MEX3C variant 6; MEX3C variant 9; ring finger and KH domain containing 2; RING finger and KH domain-containing protein 2; RING finger protein 194; RING-type E3 ubiquitin transferase MEX3C; Rkhd2; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C; RNF194
Gene Symbols MEX3C
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RKHD2. Recombinant protein control fragment (Product #RP-98271).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 51320
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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