Invitrogen™ RKHD2 Polyclonal Antibody

Catalog No.	Quantity
PIPA5100610	100 μL

Catalog No. PIPA5100610

Supplier: Invitrogen™ PA5100610

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total MEX3C.

Rkhd2, also known as MEX3C is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd2, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. It has been suggested that genetic variations in Rkhd2 may be associated with susceptibility to essential hypertension type 8. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

Specifications

• Antigen: RKHD2
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene: MEX3C
• Gene Accession No.: Q05A36, Q5U5Q3
• Gene Alias: A130001D14Rik; BC035207; BM-013; mex-3 homolog C; mex3 homolog C (C. elegans); mex-3 RNA binding family member C; Mex3c; MEX-3C; MEX3C variant 1; MEX3C variant 10; MEX3C variant 11; MEX3C variant 2; MEX3C variant 3; MEX3C variant 4; MEX3C variant 5; MEX3C variant 6; MEX3C variant 9; ring finger and KH domain containing 2; RING finger and KH domain-containing protein 2; RING finger protein 194; RING-type E3 ubiquitin transferase MEX3C; Rkhd2; RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein MEX3C; RNF194
• Gene Symbols: MEX3C
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human MEX3C(Accession Q5U5Q3), corresponding to amino acid residues S562-F612.
• Purification Method: Affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 240396, 51320
• Target Species: Human, Mouse
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov