Invitrogen™ RKHD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA566520

Catalog No. PIPA566520

Description

Immunogen sequence: THIAVRTGKIL EYNNENDFLA GSPDAAIDSR YSDAWRVHQP GCKPLSTFRQ NSLGCI Highest antigen sequence identity to the following orthologs - mouse 91%, rat 91%.

Rkhd4, also known as MEX3A is a member of a novel family of four homologous human MEX3 proteins each containing two heterogeneous nuclear ribonucleoprotein K homology (KH) domains and one carboxy-terminal RING finger module. MEX3 proteins, including Rkhd4, are phosphoproteins that bind RNA through their KH domains and shuttle between the nucleus and the cytoplasm via the CRM1 export pathway. These proteins are a novel family of evolutionarily conserved RNA-binding proteins, differentially recruited to P bodies and potentially involved in post-transcriptional regulatory mechanisms. While Rkhd2 has been suggested to be associated with susceptibility to essential hypertension type 8, the function of Rkhd4 remains unknown. Rkhd3 and Rkhd4, but not Rkhd2, co-localize with both the hDcp1a decapping factor and Argonaute (Ago) proteins in processing bodies (P bodies), recently characterized as centers of mRNA turnover.

Specifications

• Antigen: RKHD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: MEX3A
• Gene Alias: 2700083E18Rik; Gm411; mex3 homolog A; mex3 homolog A (C. elegans); mex-3 RNA binding family member A; MEX3A; MEX-3A; RGD1564904; ring finger and KH domain containing 4; ring finger and KH domain containing protein; RING finger and KH domain-containing protein 4; RKHD4; RNA-binding protein MEX3A
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 92312
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: A1L020
• Gene Symbols: MEX3A
• Immunogen: Recombinant Human RKHD4. Recombinant protein control fragment (Product #RP-107187).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov