Tocris™ RKI 1447 dihydrochloride

Potent and selective ROCK inhibitor; antitumor

Manufacturer: Tocris™ 5061/10

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Catalog No. 50-611-0R

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For Research Use Only


    Specifications

    Product Type RKI 1447 dihydrochloride
    Inhibitors RKI 1447 dihydrochloride
    Purity >99
    Molecular Weight 399.29
    Quantity 10mg

    Potent and selective ROCK inhibitor (IC50 values are 6.2 and 14.5nM for ROCK2 and ROCK1 respectively); suppresses phosphorylation of ROCK substrates MLC-2 and MYPT-1 in human cancer cells, but has no effect on the phosphorylation levels of Akt, MEK, and S6 kinase. Displays anti-invasive and antitumor activities in breast cancer cells.

    • Chemical Name: N-[(3-Hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]urea dihydrochloride
    • Formula: C16H14N4O2S.2HCl
    • Solubility: Soluble to 10mM in water with gentle warming and to 100mM in DMSO
    • Purity: >99

  • Description & Specifications

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