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Invitrogen™ RNAse H2A Polyclonal Antibody
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Catalog No. PIPA520667
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100 μg
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Catalog No. Quantity
PIPA520667 100 μg
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Catalog No. PIPA520667 Supplier Invitrogen™ Supplier No. PA520667
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Description

Rabbit Polyclonal Antibody

A suggested positive control is Hela cell lysate. PA5-20667 can be used with blocking peptide PEP-0787.

Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNAse H2A
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene RNASEH2A
Gene Accession No. O75792, Q5U209, Q9CWY8
Gene Alias 2400006P09Rik; AGS4; Aicardi-Goutieres syndrome 4 protein; hypothetical protein LOC512830; hypothetical protein MGC56307; JUNB; ribonuclease H2 subunit A; ribonuclease H2, large subunit; ribonuclease H2, subunit A; ribonuclease HI; ribonuclease HI large subunit; Ribonuclease HI subunit A; ribonuclease HI, large subunit; RNase H(35); RNase H2 subunit A; RNase HI large subunit; Rnaseh2a; RNASEHI; RNHIA; RNHL; zgc:56307
Gene Symbols RNASEH2A
Host Species Rabbit
Immunogen A 17 amino acid peptide near the center of human RNAse H2A.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10535, 364974, 69724
Target Species Human, Mouse, Rat
Content And Storage Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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