Invitrogen™ RNASE3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575363

Catalog No. PIPA575363

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

ECP (eosinophil cationic protein), also known as RNS3 or RNASE3 (ribonuclease, RNase A family, 3), is a 160 amino acid potent cytotoxic secretory protein that belongs to the pancreatic ribonuclease family. ECP localizes to the granule matrix of the eosinophil and is involved in the immune response system. ECP is a cytotoxin, neurotoxin and helminthotoxin that is secreted by activated human eosinophils. ECP exhibits anti-parasitic, antibacterial and ribonucleolytic activities. It has been suggested that ECP induces the neurotoxic effect known as the Gordon phenomenon, a syndrome manifested by ataxia, muscular rigidity, paralysis and tremor that may lead to death. ECP is considered a marker of eosinophilic inflammation and high levels have been found in cases of active asthma and other allergic diseases.

Specifications

• Antigen: RNASE3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNASE3
• Gene Alias: cytotoxic ribonuclease; Ear11; EAR-11; Ear3; ECP; Eosinophil cationic protein; eosinophil cationic protein-like; eosinophil cationic-type ribonuclease 3; Eosinophil secondary granule ribonuclease 11; eosinophil-associated ribonuclease 3; eosinophil-associated, ribonuclease A family, member 3; LOC100361866; mR3; MR-3; murine ribonuclease 3; RAF1; Ribonuclease 3; ribonuclease A family member 3; ribonuclease, RNase A family 3; ribonuclease, RNase A family, 3; RNase 3; RNASE3; RNS3
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 100361866, 53876, 6037
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide; pH 7.2
• Gene Accession No.: O35290, P12724
• Gene Symbols: Ear3, LOC100361866, RNASE3
• Immunogen: Synthetic peptide corresponding to amino acids 130-160 of Human ECP.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG