Invitrogen™ RNaseL Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA576443

Catalog No. PIPA576443

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.

Specifications

• Antigen: RNaseL
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNASEL
• Gene Alias: 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNAase; 2-5A-dependent RNase; E230029I04Rik; I79_009550; interferon-induced 2-5A-dependent RNase; PRCA1; Ribonuclease 4; ribonuclease L; ribonuclease L (2 5-oligoisoadenylate synthetase-dependent); ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent); ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent); ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L; Rnasel; RNS4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 24014, 359726, 6041
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q05823, Q05921
• Gene Symbols: RNASEL
• Immunogen: Recombinant fusion protein of human RNASEL.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov