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Invitrogen™ RNaseL Polyclonal Antibody
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Catalog No. PIPA582024
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100 μL
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Catalog No. Quantity
PIPA582024 100 μL
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Catalog No. PIPA582024 Supplier Invitrogen™ Supplier No. PA582024
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: HGAKEDFHPP AEDWKPQSSH WGAALKDLHR IYRPMIGKLK FFIDEKYKIA DTSEGGIYLG FYEKQEVAVK TFCEGSPRAQ REVSCLQSSR ENSHLVTFYG SESHRGHLFV CVTLCEQTLE ACLDVHRGED VENEEDEFAR NVLSSI Highest antigen sequence indentity to the following orthologs: Mouse - 58%, Rat - 58%.

A virally induced endoribonuclease, RNase L is the terminal factor of the anti-viral action of interferon. Activation of RNase L results in inhibition of viral proliferation. Activation of RNase L has also been determined to degrade RNA, thus, initiating a cellular stress response, inducing apoptosis. Since mutations in RNase L relate to an increased incidence of prostate cancer, the activation of RNase L functions in counteracting prostate cancer, via apoptosis.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNaseL
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RNASEL
Gene Accession No. Q05823
Gene Alias 2',5'-oligoisoadenylate synthetase-dependent; 2-5A-dependent ribonuclease; 2-5A-dependent RNAase; 2-5A-dependent RNase; E230029I04Rik; I79_009550; interferon-induced 2-5A-dependent RNase; PRCA1; Ribonuclease 4; ribonuclease L; ribonuclease L (2 5-oligoisoadenylate synthetase-dependent); ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent); ribonuclease L (2, 5-oligoisoadenylate synthetase-dependent); ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent); RNase L; Rnasel; RNS4
Gene Symbols RNASEL
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RNASEL. Recombinant protein control fragment (Product #RP-102053).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 6041
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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