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Tocris Bioscience™ RNB 61

Catalog No. 883510
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10 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Highly potent and selective CB2R agonist

RNB 61 is a highly potent and selective cannabinoid CB2 receptor (CB2R) agonist (Ki = 0.57 nM). RNB 61 shows >5000-fold selectivity for hCB2R over hCB1R. In vivo, RNB 61 inhibits the FSK-induced cAMP formation on mouse, rat, and dog CB2Rs (EC50 values ranging from 0.13 to 1.86 nM). RNB 61 has a a peripherally restricted action and exerts a nephroprotective and/or antifibrotic effects in animal models of kidney disease.

Specifications

Chemical Name or Material N-[(3E)-5-tert-Butyl-2-(cyclobutylmethyl)-1-methyl-1,2-dihydro-3H-pyrazol-3-ylidene]-2-(2-hydroxy-2-methylpropoxy)-5-(trifluoromethyl)benzamide
CAS 1217403-51-4
Quantity 10 mg
Target Cannabinoid R2/CB2 Agonists
Molecular Formula C25H34F3N3O3
Purity 0.97
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