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Invitrogen™ RNF11 Polyclonal Antibody
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Catalog No. PIPA581252
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100 μL
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PIPA581252 100 μL
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Catalog No. PIPA581252 Supplier Invitrogen™ Supplier No. PA581252
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Description

Rabbit Polyclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for Human RNF11.

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF11
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene RNF11
Gene Accession No. Q9Y3C5
Gene Alias CGI-123; N4wbp2; NEDD4 WW domain-binding protein 2; RING finger protein 11; Rnf11; Sid 1669; SID1669
Gene Symbols RNF11
Host Species Rabbit
Immunogen A synthetic peptide corresponding to the center region of the Human RNF11.
Purification Method Antigen Affinity Chromatography, Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26994
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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