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Invitrogen™ RNF11 Polyclonal Antibody
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Catalog No. PIPA597009
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100 μL
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PIPA597009 100 μL
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Catalog No. PIPA597009 Supplier Invitrogen™ Supplier No. PA597009
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: MGNCLKSPTS DDISLLHESQ SDRASFGEGT EPDQEPPPPY QEQVPVPVYH PTPSQTRLAT QLTEEEQIRI AQRIGLIQHL PKGVYDPGRD GSEKKIRECV ICMMDFVYGD PIRFLPCMHI YHLDCIDDWL MRSFTCPSCM EPVDAALLSS YETN; Positive Samples: Mouse kidney, Rat liver; Cellular Location: Cytoplasm, Early endosome, Nucleus, Recycling endosome.

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF11
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 0.69 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene RNF11
Gene Accession No. Q9QYK7
Gene Alias CGI-123; N4wbp2; NEDD4 WW domain-binding protein 2; RING finger protein 11; Rnf11; Sid 1669; SID1669
Gene Symbols RNF11
Host Species Rabbit
Immunogen Recombinant fusion protein containing a sequence corresponding to amino acids 1-154 of human RNF11 (NP_0551871).
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 29864, 689577
Target Species Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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