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RNF11 Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501988877
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50-198-8877 100 μL
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Catalog No. 50-198-8877 Supplier Bioss Supplier No. BS9176R
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Description

Rabbit Polyclonal Antibody

Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates ′Lys-63′ polyubiquitin chains on RIPK1 and catalyzes the formation of ′Lys-48′-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.

Specifications

Antigen RNF11
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene RNF11
Gene Accession No. Q9Y3C5
Gene Alias CGI-123; N4wbp2; NEDD4 WW domain-binding protein 2; RING finger protein 11; Rnf11; Sid 1669; Sid1669
Gene Symbols RNF11
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human RNF11.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 26994
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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