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Invitrogen™ RNF111 Polyclonal Antibody

Catalog No. PIPA558448
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100 μL
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Catalog No. Quantity
PIPA558448 100 μL
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Catalog No. PIPA558448 Supplier Invitrogen™ Supplier No. PA558448

Description

Rabbit Polyclonal Antibody

Immunogen sequence: TLKVDMKSEI PSDAPKTQES LKGILLHPEP IGAAKSFPAG VEMINSKVGN EFSHLCDDSQ KQEKEMNGNQ QEQEKSLVVR KKRKSQQAGP SYVQNCVKEN QGI Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 85%.

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
TRUSTED_SUSTAINABILITY

Specifications

Antigen RNF111
Applications Immunohistochemistry (Paraffin), Immunocytochemistry
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene RNF111
Gene Accession No. Q6ZNA4
Gene Alias ARK; Arkadia; E3 ubiquitin-protein ligase Arkadia; hRNF111; ring finger 111; RING finger protein 111; RING-type E3 ubiquitin transferase Arkadia; Rnf111
Gene Symbols RNF111
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human RNF111.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 54778
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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