Invitrogen™ RNF111 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558449

Catalog No. PIPA558449

Description

Immunogen sequence: GTPSDEDNDS SFSDCLSSPS SSLHFGDSDT VTSDEDKEVS VRHSQTILNA KSRSHSARSH KWPRTETESV SGLLMKRPCL HGSSLRRLPC Highest antigen sequence identity to the following orthologs: Mouse - 81%, Rat - 86%.

The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].

Specifications

• Antigen: RNF111
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: RNF111
• Gene Alias: ARK; Arkadia; E3 ubiquitin-protein ligase Arkadia; hRNF111; ring finger 111; RING finger protein 111; RING-type E3 ubiquitin transferase Arkadia; Rnf111
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54778, 93836
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6ZNA4, Q99ML9
• Gene Symbols: RNF111
• Immunogen: Recombinant protein corresponding to Human RNF111. Recombinant protein control fragment (Product #RP-98114).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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